Lady Gaga is scheduled to perform during Tuesday’s ceremony at London’s Earl’s Court arena.
She’s nominated for best international female artist, best album and breakthrough act of the year.
Florence and the Machine, Pixie Lott and Lily Allen also have three nominations each.
Other Brits performers include Jay-Z, Alicia Keys and Lily Allen. A video message from Prince Harry is scheduled to give the show a royal stamp of approval.
International nominees include Bruce Springsteen, Eminem, Jay-Z, Michael Buble and Shakira.
The awards are the British equivalent of the Grammys, with most winners selected by a vote of more than 1,000 industry members.